The electrocoagulation have been considered a promising technology for wastewater food treatment. This paper evaluates the application of electrocoagulation for the treatment of poultry slaughterhouse wastewater using two types of electrode, iron and aluminum. The initial pH, the electrolysis time and the electrical current density were used as the operating variables. The optimal operating conditions for each electrode were validated by applying the Response Surface Methodology (RSM). It was observed that the best conditions for Chemical Oxygen Demand (COD) reduction were the use of aluminum electrodes with electrolysis time of 40 minutes, initial pH of 4,0 and electrical current density of 30 A·m-2. These conditions resulted in a COD removal of 86% with a final pH of 7,5. In the validation it was found a little over-prediction and a good fit for the total removal of COD with a bias and accuracy factor of 1,04 and 1,16 respectively. The developed models aim to facilitate the values prediction of process variables that should be favored when using the electrolytic method on a larger scale or in additional tests for poultry slaughterhouse wastewater treatment.